United States securities and exchange commission logo August 17, 2022 Bernice E. Bell Chief Financial Officer AGNC Investment Corp. 2 Bethesda Metro Center, 12th Floor Bethesda, Maryland 20814 Re: AGNC Investment Corp. Form 10-K for fiscal year ended December 31, 2021 Filed February 23, 2022 File No. 001-34057 Dear Ms. Bell: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Real Estate & Construction