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  <xs:element id="agnc_CostofSaleofFairValueOptionSecurities" abstract="false" name="CostofSaleofFairValueOptionSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate" abstract="false" name="InterestRateSwapsLinkedtoSecuredOvernightFinancingRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_A2Daysto1MonthMember" abstract="true" name="A2Daysto1MonthMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_PreferredStockCLiquidationPreferenceValue" abstract="false" name="PreferredStockCLiquidationPreferenceValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="agnc_LessThanOrEqualToOneYearMember" abstract="true" name="LessThanOrEqualToOneYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
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  <xs:element id="agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" abstract="false" name="CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="agnc_GainLossOnOtherDebt" abstract="false" name="GainLossOnOtherDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" abstract="false" name="NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" abstract="false" name="GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" abstract="false" name="ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
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  <xs:element id="agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" abstract="false" name="PaymentsToAcquireNonAgencyMortgageBackedSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="agnc_CostOfSaleOfAvailableForSaleSecuities" abstract="false" name="CostOfSaleOfAvailableForSaleSecuities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="agnc_PreferredStockDividendPaymentRateVariableRateSpread" abstract="false" name="PreferredStockDividendPaymentRateVariableRateSpread" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" abstract="false" name="ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_A4.5CouponMember" abstract="true" name="A4.5CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" abstract="false" name="RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_WeightedAverageForwardStartDate" abstract="false" name="WeightedAverageForwardStartDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="agnc_A2016EquityPlanMember" abstract="true" name="A2016EquityPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_USgovernmentsecuritiesTableTextBlock" abstract="false" name="USgovernmentsecuritiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_NonAgencySecuritiesatFairValue" abstract="false" name="NonAgencySecuritiesatFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_StockRepurchasedDuringPeriodTradeDateValue" abstract="false" name="StockRepurchasedDuringPeriodTradeDateValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock" abstract="false" name="ReverseRepurchaseAgreementsPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" abstract="false" name="NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_IncludesSoldButNotYetSettledSecuritiesMember" abstract="true" name="IncludesSoldButNotYetSettledSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_PreferredStockCValueIssued" abstract="false" name="PreferredStockCValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_ManagementAgreementTextBlock" abstract="false" name="ManagementAgreementTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_WeightedAverageCouponRate" abstract="false" name="WeightedAverageCouponRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" abstract="false" name="GrossAmountOffsetintheConsolidatedBalanceSheets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" abstract="false" name="AgencySecuritiesPledgedAsCollateralAccruedInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" abstract="false" name="ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" abstract="false" name="RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_WeightedAverageForwardStartDays" abstract="false" name="WeightedAverageForwardStartDays" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="agnc_IntendedAnnualDistributionofTaxableNetIncome" abstract="false" name="IntendedAnnualDistributionofTaxableNetIncome" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_GrossGainLossofInvestmentSecuritiesMember" abstract="true" name="GrossGainLossofInvestmentSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_InterestRateSwapsExcludingForwardStartingMember" abstract="true" name="InterestRateSwapsExcludingForwardStartingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_FollowOnPublicOfferingMember" abstract="true" name="FollowOnPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_PreferredStockBLiquidationPreferenceValue" abstract="false" name="PreferredStockBLiquidationPreferenceValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DerivativesByMaturityAxis" abstract="true" name="DerivativesByMaturityAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" abstract="true" name="Depositoryshareseachrepresentinga11000thinterestinashareof6.875SeriesDFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" abstract="false" name="FuturePrepaymentRateAssumptionOfInvestmentPortfolio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" abstract="false" name="AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" abstract="false" name="LossOnDerivativeInstrumentsAndTradingSecuritiesNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DerivativeInstrumentsDesignationDomain" abstract="true" name="DerivativeInstrumentsDesignationDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" abstract="false" name="PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" abstract="false" name="SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" abstract="false" name="AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_ComponentsOfInvestmentSecuritiesTableTextBlock" abstract="false" name="ComponentsOfInvestmentSecuritiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_A10YearMaturityMember" abstract="true" name="A10YearMaturityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_OffsettingAssetsAndLiabilitiesLineItems" abstract="true" name="OffsettingAssetsAndLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_EquityIncentivePlansAbstract" abstract="true" name="EquityIncentivePlansAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" abstract="true" name="GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost" abstract="false" name="AgencySecuritiesPledgedAsCollateralAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" abstract="false" name="AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_StockRepurchasedDuringPeriodSettledAfterShares" abstract="false" name="StockRepurchasedDuringPeriodSettledAfterShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate" abstract="false" name="InterestRateSwapsLinkedtoOvernightIndexSwapRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_RequiredAnnualDistributionOfTaxableNetIncome" abstract="false" name="RequiredAnnualDistributionOfTaxableNetIncome" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_Maturity31To59DaysMember" abstract="true" name="Maturity31To59DaysMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_AAARatingMember" abstract="true" name="AAARatingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_USGovernmentFuturesSecuritiesTableTextBlock" abstract="false" name="USGovernmentFuturesSecuritiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" abstract="false" name="ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_WeightedAverageLifeOtherDebt" abstract="false" name="WeightedAverageLifeOtherDebt" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" abstract="true" name="RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" abstract="false" name="SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_UnderPrimeBrokerAgreementsMember" abstract="true" name="UnderPrimeBrokerAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_TaxCharacterizationAxis" abstract="true" name="TaxCharacterizationAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_FairValueOfCmoSecuritiesDirectlyHeld" abstract="false" name="FairValueOfCmoSecuritiesDirectlyHeld" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_NonAgencyMember" abstract="true" name="NonAgencyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities" abstract="false" name="ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_A7to9monthsMember" abstract="true" name="A7to9monthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_TBAandForwardSettlingAgencySecuritiesMember" abstract="true" name="TBAandForwardSettlingAgencySecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" abstract="false" name="NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_OptionsAtCost" abstract="false" name="OptionsAtCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_LongTermCapitalGainDividendPerShare" abstract="false" name="LongTermCapitalGainDividendPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:perShareItemType"/>
  <xs:element id="agnc_A3.5CouponMember" abstract="true" name="A3.5CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember" abstract="true" name="SaleOfTbaAndForwardSettlingAgencySecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_Governmentbondsownedandsoldshortnet" abstract="false" name="Governmentbondsownedandsoldshortnet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_NotRatedMember" abstract="true" name="NotRatedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_DirectorPlanAbstract" abstract="true" name="DirectorPlanAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" abstract="true" name="RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_PreferredStockBValueIssued" abstract="false" name="PreferredStockBValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DocumentAndEntityInformationAbstract" abstract="true" name="DocumentAndEntityInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_InterestrateswapreceiverMember" abstract="true" name="InterestrateswapreceiverMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_SecuritiesbyCreditRatingTableTextBlock" abstract="false" name="SecuritiesbyCreditRatingTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" abstract="false" name="NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_SecuritizedCmoSecurities" abstract="false" name="SecuritizedCmoSecurities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PledgedAssetsAbstract" abstract="true" name="PledgedAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_PreferredStockDLiquidationPreferenceValue" abstract="false" name="PreferredStockDLiquidationPreferenceValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DerivativeByMaturityYearsAxis" abstract="true" name="DerivativeByMaturityYearsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_WeightedAverageYieldPercentage" abstract="false" name="WeightedAverageYieldPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesPar" abstract="false" name="AvailableForSaleSecuritiesPar" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" abstract="true" name="Depositaryshareseachrepresentinga11000thinterestinashareof6.125SeriesFFixedtoFloatingRateCumulativeRedeemablePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_VariableInterestEntitiesAbstract" abstract="true" name="VariableInterestEntitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_MortgageBackedSecuritiesAmortizedCost" abstract="false" name="MortgageBackedSecuritiesAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DerivativeInstrumentsDesignationAxis" abstract="true" name="DerivativeInstrumentsDesignationAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding" abstract="false" name="WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare" abstract="false" name="StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_LessThanorEqualtoThreeYearsMember" abstract="true" name="LessThanorEqualtoThreeYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_ThirtyOneToNinetyMember" abstract="true" name="ThirtyOneToNinetyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_DerivativesbyIssuerAxis" abstract="true" name="DerivativesbyIssuerAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_TaxCharacterizationDomain" abstract="true" name="TaxCharacterizationDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="agnc_GrossAmountOfRecognizedAssetsLiabilities" abstract="false" name="GrossAmountOfRecognizedAssetsLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DeferredSharesOutstanding" abstract="false" name="DeferredSharesOutstanding" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
</xs:schema>
