<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:href="agnc-20190930.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:href="agnc-20190930.xsd#ConsolidatedBalanceSheetsParentheticals" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementOfStockholdersEquity" xlink:href="agnc-20190930.xsd#ConsolidatedStatementOfStockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="agnc-20190930.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlowsCalc2" xlink:href="agnc-20190930.xsd#ConsolidatedStatementsOfCashFlowsCalc2" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:href="agnc-20190930.xsd#ConsolidatedStatementsOfComprehensiveIncome" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncomeCalc2" xlink:href="agnc-20190930.xsd#ConsolidatedStatementsOfComprehensiveIncomeCalc2" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstruments" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstruments" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTables" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:href="agnc-20190930.xsd#DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/DocumentAndEntityInformation" xlink:href="agnc-20190930.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurements" xlink:href="agnc-20190930.xsd#FairValueMeasurements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:href="agnc-20190930.xsd#FairValueMeasurementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:href="agnc-20190930.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecurities" xlink:href="agnc-20190930.xsd#InvestmentSecurities" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:href="agnc-20190930.xsd#InvestmentSecuritiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:href="agnc-20190930.xsd#NetIncomeLossPerCommonShareDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:href="agnc-20190930.xsd#NetIncomeLossPerCommonShareNotes" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/NetIncomeLossPerCommonShareTables" xlink:href="agnc-20190930.xsd#NetIncomeLossPerCommonShareTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/Organization" xlink:href="agnc-20190930.xsd#Organization" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/OrganizationDetails" xlink:href="agnc-20190930.xsd#OrganizationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssets" xlink:href="agnc-20190930.xsd#PledgedAssets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:href="agnc-20190930.xsd#PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/PledgedAssetsTables" xlink:href="agnc-20190930.xsd#PledgedAssetsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:href="agnc-20190930.xsd#RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquity" xlink:href="agnc-20190930.xsd#StockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityLongTermIncentivePlanDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityLongTermIncentivePlanDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityPreferredStockDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:href="agnc-20190930.xsd#StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/StockholdersEquityTables" xlink:href="agnc-20190930.xsd#StockholdersEquityTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEvent" xlink:href="agnc-20190930.xsd#SubsequentEvent" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SubsequentEventDetails" xlink:href="agnc-20190930.xsd#SubsequentEventDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:href="agnc-20190930.xsd#SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:href="agnc-20190930.xsd#UnauditedInterimConsolidatedFinancialStatements" xlink:type="simple" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_9C7AF85C955B591389F2C8347D17D04C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_9C7AF85C955B591389F2C8347D17D04C" xlink:to="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_7B5438F204F351FBA68393207ED17499" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_7B5438F204F351FBA68393207ED17499" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:label="loc_us-gaap_OtherLongTermDebt_B6B501198BE95D33ADA73CAB71DBE8AC" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:to="loc_us-gaap_OtherLongTermDebt_B6B501198BE95D33ADA73CAB71DBE8AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_PayablesToBrokerDealersAndClearingOrganizations" xlink:label="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_2C596BC663EF576AA28F2F7053921A74" xlink:type="locator" />
    <link:calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:to="loc_srt_PayablesToBrokerDealersAndClearingOrganizations_2C596BC663EF576AA28F2F7053921A74" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilities" xlink:label="loc_us-gaap_DerivativeLiabilities_B00204A7954F534F807E01DCEF60BEA4" xlink:type="locator" />
    <link:calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:to="loc_us-gaap_DerivativeLiabilities_B00204A7954F534F807E01DCEF60BEA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_0A4DB99CC5AF5C59A92DC9F2F8D3EBA6" xlink:type="locator" />
    <link:calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:to="loc_us-gaap_DividendsPayableCurrentAndNoncurrent_0A4DB99CC5AF5C59A92DC9F2F8D3EBA6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" xlink:label="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A03844720023538988A0A026B52E67B5" xlink:type="locator" />
    <link:calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:to="loc_agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue_A03844720023538988A0A026B52E67B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_B81E99D70D1950FDA389B6EC66F55285" xlink:type="locator" />
    <link:calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_03C72E1EA1ED5501BBECD4533B3AF57C" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_B81E99D70D1950FDA389B6EC66F55285" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_31B3482D6B4E539F81298EA2E512877B" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_9C7AF85C955B591389F2C8347D17D04C" xlink:to="loc_us-gaap_StockholdersEquity_31B3482D6B4E539F81298EA2E512877B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_D0D05187325654A4BC673BADC7428D86" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_31B3482D6B4E539F81298EA2E512877B" xlink:to="loc_us-gaap_PreferredStockValue_D0D05187325654A4BC673BADC7428D86" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_1123AC819C34521588AAD5EF13BAC96C" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_31B3482D6B4E539F81298EA2E512877B" xlink:to="loc_us-gaap_CommonStockValue_1123AC819C34521588AAD5EF13BAC96C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_68454D6F710B545BAA7692110544029B" xlink:type="locator" />
    <link:calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_31B3482D6B4E539F81298EA2E512877B" xlink:to="loc_us-gaap_AdditionalPaidInCapital_68454D6F710B545BAA7692110544029B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_25F7B954DDFD531BA859BACDDFB5EC53" xlink:type="locator" />
    <link:calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_31B3482D6B4E539F81298EA2E512877B" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_25F7B954DDFD531BA859BACDDFB5EC53" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_9361B5A1E7F7580EB4021D474BE95CAA" xlink:type="locator" />
    <link:calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_31B3482D6B4E539F81298EA2E512877B" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_9361B5A1E7F7580EB4021D474BE95CAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_DB18A774D44B5E1C88FA9B56D742A8AB" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedMortgagesMortgageBackedAndAssetBackedSecuritiesAtFairValue_DB18A774D44B5E1C88FA9B56D742A8AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets" xlink:label="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_A007849DAB80509B976CBAB21D360944" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_VariableInterestEntityConsolidatedCarryingAmountAssets_A007849DAB80509B976CBAB21D360944" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedOtherAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_662D735B2E3C57B6B0C271085AA07205" xlink:type="locator" />
    <link:calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedOtherAtFairValue_662D735B2E3C57B6B0C271085AA07205" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_NonAgencySecuritiesatFairValue" xlink:label="loc_agnc_NonAgencySecuritiesatFairValue_C4AF89DA17615F3A9300F02E954304EB" xlink:type="locator" />
    <link:calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_agnc_NonAgencySecuritiesatFairValue_C4AF89DA17615F3A9300F02E954304EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_1680608834325CB287A6328AEE070DD6" xlink:type="locator" />
    <link:calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedUSGovernmentAndAgencyObligationsAtFairValue_1680608834325CB287A6328AEE070DD6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_732FFF932D3358F8BE876FC0BDA4223C" xlink:type="locator" />
    <link:calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_732FFF932D3358F8BE876FC0BDA4223C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_EC827A5E09765CCCB04DE9B967DBBA96" xlink:type="locator" />
    <link:calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_EC827A5E09765CCCB04DE9B967DBBA96" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssets" xlink:label="loc_us-gaap_DerivativeAssets_8584EBA7EAA654F79B152B7BC17E51AC" xlink:type="locator" />
    <link:calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_DerivativeAssets_8584EBA7EAA654F79B152B7BC17E51AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations" xlink:label="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_4004EE0712CC5882AEC5D1294789A671" xlink:type="locator" />
    <link:calculationArc order="9" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_OtherReceivablesFromBrokerDealersAndClearingOrganizations_4004EE0712CC5882AEC5D1294789A671" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ReceivableUnderReverseRepurchaseAgreements" xlink:label="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_482E48E353E35F04976A68C11A40478F" xlink:type="locator" />
    <link:calculationArc order="10" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_agnc_ReceivableUnderReverseRepurchaseAgreements_482E48E353E35F04976A68C11A40478F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_8D75B3B995765CEAA338B2F30DDB9FC1" xlink:type="locator" />
    <link:calculationArc order="11" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_8D75B3B995765CEAA338B2F30DDB9FC1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssets" xlink:label="loc_us-gaap_OtherAssets_185F6E613969597289D65B203A5FAD2B" xlink:type="locator" />
    <link:calculationArc order="12" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_99AB22290C855FF58FAA640910990666" xlink:to="loc_us-gaap_OtherAssets_185F6E613969597289D65B203A5FAD2B" xlink:type="arc" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedBalanceSheetsParentheticals" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementOfStockholdersEquity" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_834a7bf3-d1ec-a251-04d2-cec093e0f492" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_834a7bf3-d1ec-a251-04d2-cec093e0f492" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_e170ce1e-c3a8-e8ee-88b0-37e8dd7b1d11" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_us-gaap_NetIncomeLoss_e170ce1e-c3a8-e8ee-88b0-37e8dd7b1d11" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_94f5ae99-7bd8-4f8c-5311-9522abc2f1bd" xlink:type="locator" />
    <link:calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_94f5ae99-7bd8-4f8c-5311-9522abc2f1bd" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_725ae160-1b15-a075-fa62-729d0bc8cda1" xlink:type="locator" />
    <link:calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_725ae160-1b15-a075-fa62-729d0bc8cda1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_f0b9d825-b0b9-37fd-4d25-9294a8598890" xlink:type="locator" />
    <link:calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_us-gaap_ShareBasedCompensation_f0b9d825-b0b9-37fd-4d25-9294a8598890" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_09248aab-d73c-2e49-92c1-f82b61e075b1" xlink:type="locator" />
    <link:calculationArc order="5" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_09248aab-d73c-2e49-92c1-f82b61e075b1" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome" xlink:label="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_6192b3df-b329-86c9-668f-43b8e0772a1c" xlink:type="locator" />
    <link:calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_agnc_Netunrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincome_6192b3df-b329-86c9-668f-43b8e0772a1c" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" xlink:label="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_9af8cebf-b5fc-f808-4041-43b8e03e1e56" xlink:type="locator" />
    <link:calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet_9af8cebf-b5fc-f808-4041-43b8e03e1e56" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_5550ae9d-a6e2-fc35-fc50-54521e2bfb5d" xlink:type="locator" />
    <link:calculationArc order="8" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_5550ae9d-a6e2-fc35-fc50-54521e2bfb5d" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_7c1c3153-d95c-50b8-10ed-a75d1f3d7a68" xlink:type="locator" />
    <link:calculationArc order="9" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ce0d7b63-a366-bc9b-79e1-780981e428fe" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_7c1c3153-d95c-50b8-10ed-a75d1f3d7a68" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_834a7bf3-d1ec-a251-04d2-cec093e0f492" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_c2a01d81-ead3-36c5-f410-ffd902c7fcaf" xlink:type="locator" />
    <link:calculationArc order="1" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_us-gaap_PaymentsToAcquireMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_c2a01d81-ead3-36c5-f410-ffd902c7fcaf" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities" xlink:label="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_b979d1bc-d621-e661-e926-43b8e0dc7e1a" xlink:type="locator" />
    <link:calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_agnc_PaymentsToAcquireNonAgencyMortgageBackedSecurities_b979d1bc-d621-e661-e926-43b8e0dc7e1a" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_eb5c49ca-008f-680c-44ea-7c12fadd06e6" xlink:type="locator" />
    <link:calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageBackedSecuritiesMBSCategorizedAsAvailableForSale_eb5c49ca-008f-680c-44ea-7c12fadd06e6" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities" xlink:label="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_d814d589-9bcc-573d-ef17-43b8e166d109" xlink:type="locator" />
    <link:calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_agnc_ProceedsfromsaleofCreditRiskTransferandnonAgencysecurities_d814d589-9bcc-573d-ef17-43b8e166d109" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" xlink:label="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_c63098b4-a7b8-be0c-12e3-43b8e09b7e8d" xlink:type="locator" />
    <link:calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale_c63098b4-a7b8-be0c-12e3-43b8e09b7e8d" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities" xlink:label="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_8404ba68-10fe-d243-0816-43b8e04bb552" xlink:type="locator" />
    <link:calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_agnc_PrincipalcollectionsoncreditrisktransferandnonAgencysecurities_8404ba68-10fe-d243-0816-43b8e04bb552" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_b978ae77-fef7-cb46-afee-f23498c1fbe0" xlink:type="locator" />
    <link:calculationArc order="7" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_b978ae77-fef7-cb46-afee-f23498c1fbe0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_2dce1f0e-7f83-9972-30f6-6530ebad3263" xlink:type="locator" />
    <link:calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_2dce1f0e-7f83-9972-30f6-6530ebad3263" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell" xlink:label="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_7f6eaba8-04ba-af01-41c9-ae03f6e670c8" xlink:type="locator" />
    <link:calculationArc order="9" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_us-gaap_ProceedsFromPaymentsForSecuritiesPurchasedUnderAgreementsToResell_7f6eaba8-04ba-af01-41c9-ae03f6e670c8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_79790362-8a75-c331-dfb1-f074bcef144a" xlink:type="locator" />
    <link:calculationArc order="10" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentFinancingActivities_79790362-8a75-c331-dfb1-f074bcef144a" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_b5cf64b6-8899-5a9a-328a-4f0a312ae378" xlink:type="locator" />
    <link:calculationArc order="11" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_0f07a806-a2da-6d18-a7a9-d734fad1f3b0" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_b5cf64b6-8899-5a9a-328a-4f0a312ae378" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:type="locator" />
    <link:calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_834a7bf3-d1ec-a251-04d2-cec093e0f492" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_f0d35d24-90f5-d279-b8ea-08a17fdbe9e3" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_f0d35d24-90f5-d279-b8ea-08a17fdbe9e3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfShortTermDebt" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_48142928-1201-6f98-3e39-a53c35d5b675" xlink:type="locator" />
    <link:calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_48142928-1201-6f98-3e39-a53c35d5b675" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfOtherDebt" xlink:label="loc_us-gaap_RepaymentsOfOtherDebt_49c832ca-c693-84a6-ae67-3f29a64c3833" xlink:type="locator" />
    <link:calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:to="loc_us-gaap_RepaymentsOfOtherDebt_49c832ca-c693-84a6-ae67-3f29a64c3833" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_d58ff834-f6f4-d17f-9a5a-a8f17b05a983" xlink:type="locator" />
    <link:calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_d58ff834-f6f4-d17f-9a5a-a8f17b05a983" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_0f0975d6-8500-76a0-c74f-5d2f0ed8b620" xlink:type="locator" />
    <link:calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_0f0975d6-8500-76a0-c74f-5d2f0ed8b620" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3f804297-91a1-3939-541d-a39b6288c9f9" xlink:type="locator" />
    <link:calculationArc order="6" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3f804297-91a1-3939-541d-a39b6288c9f9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_97b2cb74-f62e-ba8a-3953-eb9af3cfb8a4" xlink:type="locator" />
    <link:calculationArc order="7" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_1efd93c0-bb90-2a64-a997-3a70afaa3faa" xlink:to="loc_us-gaap_PaymentsOfDividends_97b2cb74-f62e-ba8a-3953-eb9af3cfb8a4" xlink:type="arc" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfCashFlowsCalc2" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestIncomeExpenseNet" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_3670655D741154E5B7F3DAD10952B4C7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestIncomeSecuritiesMortgageBacked" xlink:label="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_DF978EF6AA715EAB9A646CF50DCB36D0" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_3670655D741154E5B7F3DAD10952B4C7" xlink:to="loc_us-gaap_InterestIncomeSecuritiesMortgageBacked_DF978EF6AA715EAB9A646CF50DCB36D0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_E0EBA47E78A45589853432051CED9A84" xlink:type="locator" />
    <link:calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_3670655D741154E5B7F3DAD10952B4C7" xlink:to="loc_us-gaap_InterestExpense_E0EBA47E78A45589853432051CED9A84" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_A8B40DC3D3A9525E8E2EF4CD2254ECE2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_B6F9CC0B01715F3D857FCDF1FB72B871" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_A8B40DC3D3A9525E8E2EF4CD2254ECE2" xlink:to="loc_us-gaap_NetIncomeLoss_B6F9CC0B01715F3D857FCDF1FB72B871" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_103076184B995B83924FF4F295BE4879" xlink:type="locator" />
    <link:calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_A8B40DC3D3A9525E8E2EF4CD2254ECE2" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_103076184B995B83924FF4F295BE4879" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoninterestIncome" xlink:label="loc_us-gaap_NoninterestIncome_3671FF0AF660570F83651B7227DA89B9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS" xlink:label="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_0BA3ABBC642C53299D3ACBB903D1A950" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_3671FF0AF660570F83651B7227DA89B9" xlink:to="loc_us-gaap_GainLossOnSalesOfMortgageBackedSecuritiesMBS_0BA3ABBC642C53299D3ACBB903D1A950" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet" xlink:label="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_6AC5A72013E55E0C99AD41A94C340EFA" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_3671FF0AF660570F83651B7227DA89B9" xlink:to="loc_agnc_Unrealizedgainlossoninvestmentsecuritiesmeasuredatfairvaluethroughnetincomenet_6AC5A72013E55E0C99AD41A94C340EFA" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet" xlink:label="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_F185AAD88C8F519FB660501002D84B78" xlink:type="locator" />
    <link:calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_3671FF0AF660570F83651B7227DA89B9" xlink:to="loc_agnc_Gainlossonderivativeinstrumentsandothersecuritiesnet_F185AAD88C8F519FB660501002D84B78" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ManagementFeeIncome" xlink:label="loc_agnc_ManagementFeeIncome_395620A598C55257BD1F504F8251C676" xlink:type="locator" />
    <link:calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_3671FF0AF660570F83651B7227DA89B9" xlink:to="loc_agnc_ManagementFeeIncome_395620A598C55257BD1F504F8251C676" xlink:type="arc" />
    <link:loc xlink:href="agnc-20190930.xsd#agnc_ComprehensiveIncomeAvailableToCommonShareholders" xlink:label="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_B6F7DBBFD1485582A96EA425283D9B81" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_034554F96F295BC1A0451215F1ABAF7E" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_B6F7DBBFD1485582A96EA425283D9B81" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_034554F96F295BC1A0451215F1ABAF7E" xlink:type="arc" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_034554F96F295BC1A0451215F1ABAF7E" xlink:to="loc_us-gaap_NetIncomeLoss_B6F9CC0B01715F3D857FCDF1FB72B871" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_0708A7F7032F5708AF9F1D833BF69B53" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_034554F96F295BC1A0451215F1ABAF7E" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_0708A7F7032F5708AF9F1D833BF69B53" xlink:type="arc" />
    <link:calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_agnc_ComprehensiveIncomeAvailableToCommonShareholders_B6F7DBBFD1485582A96EA425283D9B81" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_103076184B995B83924FF4F295BE4879" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_EE8EAC51E4B25A9CA587A78259A144D9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LaborAndRelatedExpense" xlink:label="loc_us-gaap_LaborAndRelatedExpense_AEADE2D08A4A55F0ADE811006B536357" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_EE8EAC51E4B25A9CA587A78259A144D9" xlink:to="loc_us-gaap_LaborAndRelatedExpense_AEADE2D08A4A55F0ADE811006B536357" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_C41C5F9696C75E748D42F5EBDBE1D4A0" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_EE8EAC51E4B25A9CA587A78259A144D9" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_C41C5F9696C75E748D42F5EBDBE1D4A0" xlink:type="arc" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://www.agnc.com/role/ConsolidatedStatementsOfComprehensiveIncomeCalc2" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstruments" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsEffectOfDerivativeInstrumentsNotDesignatedAsHedgesOnComprehensiveIncomeStatementDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsFairValueInformationDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsNarrativeDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsRemainingInterestRateSwapTermDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsSummaryOfOutstandingInterestRateSwapsDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsTbaSecuritiesByCouponAndIssuerDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DerivativeAndOtherHedgingInstrumentsUsTreasurySecuritiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/DocumentAndEntityInformation" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurements" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/FairValueMeasurementsTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecurities" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesComponentsOfInvestmentSecuritiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesInvestmentSecuritiesSummaryOfInvestmentInAgencySecurityDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSecuritiesByCreditRatingDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfAgencySecuritiesEstimatedWeightedAverageLifeClassificationsDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfChangesInAccumulatedOciForAvailableForSaleSecurityDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfContinuousUnrealizedLossPositionsOfAvailableForSaleSecurityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_1455D36EBC875F3DBC0102F0FBA18F88" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_8007CEC970D55067B57E9837E5CBC882" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_1455D36EBC875F3DBC0102F0FBA18F88" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_8007CEC970D55067B57E9837E5CBC882" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_119572016BAD5297AD235F920908C101" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_1455D36EBC875F3DBC0102F0FBA18F88" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_119572016BAD5297AD235F920908C101" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_0B5A54B0587E58E8BD2285680723FEAE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_15D2EC9AA2F85F21A92002D6C96EE46B" xlink:type="locator" />
    <link:calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_0B5A54B0587E58E8BD2285680723FEAE" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_15D2EC9AA2F85F21A92002D6C96EE46B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_7A932159C4715C7B85459460E9C9A1D4" xlink:type="locator" />
    <link:calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_0B5A54B0587E58E8BD2285680723FEAE" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_7A932159C4715C7B85459460E9C9A1D4" xlink:type="arc" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesSummaryOfNetGainFromSaleOfAgencySecuritiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/InvestmentSecuritiesTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareNotes" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/NetIncomeLossPerCommonShareTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/Organization" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/OrganizationDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssets" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedAsCollateralDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsAssetsPledgedFromCounterpartiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsNarrativeDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsOffsettingAssetsAndLiabilitiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsRepurchaseAgreementsWithCounterpartiesGreaterThanOrEqualTo5OfEquityAtRiskDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsSecuritiesPledgedAsCollateralDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/PledgedAssetsTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndOtherDebtRepurchaseArrangementsAndWeightedAverageInterestRatesClassifiedByOriginalMaturitiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreements" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsFederalHomeLoanBankAdvancesAndWeightedAverageInterestRatesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsNarrativeDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/RepurchaseAgreementsAndReverseRepurchaseAgreementsTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquity" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityAtTheMarketOfferingProgramDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityCommonStockRepurchaseProgramDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityDividendReinvestmentAndDirectStockPurchasePlanDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityFollowOnEquityOfferingsDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityLongTermIncentivePlanDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityPreferredStockDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityScheduleOfDividendsDeclaredDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/StockholdersEquityTables" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/SubsequentEvent" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/SubsequentEventDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesAccountingPoliciesPolicies" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesGoodwillAndIntangibleAssetsDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/SummaryOfSignificantAccountingPoliciesVariableInterestEntitiesDetails" xlink:type="extended" />
  <link:calculationLink xlink:role="http://www.agnc.com/role/UnauditedInterimConsolidatedFinancialStatements" xlink:type="extended" />
</link:linkbase>
