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  <xsd:element id="agnc_Governmentbondsownedandsoldshortnet" name="Governmentbondsownedandsoldshortnet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" name="GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_GreaterThanFiveYearsMember" name="GreaterThanFiveYearsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" name="GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" name="GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_GreaterThanTenYearsMember" name="GreaterThanTenYearsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" name="GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_GrossAmountOfRecognizedAssetsLiabilities" name="GrossAmountOfRecognizedAssetsLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" name="GrossAmountOffsetintheConsolidatedBalanceSheets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" name="GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" name="GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="agnc_IncludesSoldButNotYetSettledSecuritiesMember" name="IncludesSoldButNotYetSettledSecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_IntendedAnnualDistributionofTaxableNetIncome" name="IntendedAnnualDistributionofTaxableNetIncome" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_InterestIncomePolicyTextBlock" name="InterestIncomePolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_InterestOnlyAndPrincipalOnlyStripMember" name="InterestOnlyAndPrincipalOnlyStripMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_InterestRateDerivativeAssetsAtAmortizedCost" name="InterestRateDerivativeAssetsAtAmortizedCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" name="InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_InterestRateSwapsExcludingForwardStartingMember" name="InterestRateSwapsExcludingForwardStartingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_InvestmentInMortgageBackedSecuritiesTextBlock" name="InvestmentInMortgageBackedSecuritiesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_LessThanOrEqualToOneYearMember" name="LessThanOrEqualToOneYearMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_LossOnDerivativeInstrumentsAndTradingSecuritiesNet" name="LossOnDerivativeInstrumentsAndTradingSecuritiesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_Maturity31To59DaysMember" name="Maturity31To59DaysMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_Maturity60To90DaysMember" name="Maturity60To90DaysMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_MortgageBackedSecuritiesAmortizedCost" name="MortgageBackedSecuritiesAmortizedCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_MortgageBackedSecuritiesUnrealizedGain" name="MortgageBackedSecuritiesUnrealizedGain" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_MortgageBackedSecuritiesUnrealizedLoss" name="MortgageBackedSecuritiesUnrealizedLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" name="NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" name="NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_NetPeriodicInterestRateCostsOnSwaps" name="NetPeriodicInterestRateCostsOnSwaps" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="agnc_NonAgencySecuritiesUnrealizedGain" name="NonAgencySecuritiesUnrealizedGain" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_NonAgencySecuritiesUnrealizedLoss" name="NonAgencySecuritiesUnrealizedLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="agnc_NonAgencySecuritiesatFairValue" name="NonAgencySecuritiesatFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" name="NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" name="NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" name="NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="agnc_ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" name="ObligationToReturnSecuritiesBorrowedUnderReverseRepurchaseAgreementsAtFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="agnc_OffsettingAssetsAndLiabilitiesLineItems" name="OffsettingAssetsAndLiabilitiesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_OffsettingAssetsAndLiabilitiesTable" name="OffsettingAssetsAndLiabilitiesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_OptionsAtCost" name="OptionsAtCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" name="OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_OtherDerivativesMember" name="OtherDerivativesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_PayerSwaptionMember" name="PayerSwaptionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_PledgedAssetsAbstract" name="PledgedAssetsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_PledgedAssetsTextBlock" name="PledgedAssetsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_PreferredStockAuthorizedButNotIssued" name="PreferredStockAuthorizedButNotIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="agnc_PreferredStockPercentInterestPerShare" name="PreferredStockPercentInterestPerShare" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_PrincipalBalanceOfSecuritiesHeldAsCollateral" name="PrincipalBalanceOfSecuritiesHeldAsCollateral" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" name="ProceedsFromPrincipalCollectionOfMortgageBackedSecuritiesCategorizedAsAvailableForSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" name="PurchasesOfTbasAndForwardSettlingAgencySecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_Purchasesofcreditrisktransfersecurities" name="Purchasesofcreditrisktransfersecurities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="agnc_ReceivableUnderReverseRepurchaseAgreements" name="ReceivableUnderReverseRepurchaseAgreements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="agnc_ReceiverSwaptionMember" name="ReceiverSwaptionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" name="RepurchaseAgreementsWeightedAverageDaysToMaturity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" name="RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" name="RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_RequiredAnnualDistributionOfTaxableNetIncome" name="RequiredAnnualDistributionOfTaxableNetIncome" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" name="RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="agnc_ReverseRepurchaseAgreementsMember" name="ReverseRepurchaseAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_RiskOfRepurchaseAgreementToStockholdersEquity" name="RiskOfRepurchaseAgreementToStockholdersEquity" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="agnc_SaleOfTbaAndForwardSettlingAgencySecuritiesMember" name="SaleOfTbaAndForwardSettlingAgencySecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" name="ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" name="ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" name="ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" name="ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" name="ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock" name="ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock" name="ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" name="SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_SecuritiesRemeasuredatFairValueMember" name="SecuritiesRemeasuredatFairValueMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" name="SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain" name="SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedGain" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="agnc_SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss" name="SecuritiesRemeasuredatFairValueThroughEarningsGrossUnrealizedLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="agnc_SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost" name="SecuritiesRemeasuredatFairValuethroughearningsAmortizedCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_SecuritiesremeasuredatfairvaluethroughearningsParValue" name="SecuritiesremeasuredatfairvaluethroughearningsParValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_SecuritizedCmoSecurities" name="SecuritizedCmoSecurities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_SpreadOverLibor" name="SpreadOverLibor" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock" name="SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" name="SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock" name="SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_TBAandForwardSettlingAgencySecuritiesMember" name="TBAandForwardSettlingAgencySecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" name="TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_ThirtyOneToNinetyMember" name="ThirtyOneToNinetyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_TotalAgencySecurities" name="TotalAgencySecurities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest" name="TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest" name="TotalFairValueofSecuritiesPledgedandAccruedInterest" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_TotalReclassOfOtherComprehensiveIncome" name="TotalReclassOfOtherComprehensiveIncome" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="agnc_TotalSecurities" name="TotalSecurities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_TradingSecuritiesAddedDuringthePeriod" name="TradingSecuritiesAddedDuringthePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="agnc_TransfersBetweenHierarchyLevels" name="TransfersBetweenHierarchyLevels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_USGovernmentFuturesSecuritiesTableTextBlock" name="USGovernmentFuturesSecuritiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_USgovernmentsecuritiesTableTextBlock" name="USgovernmentsecuritiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_UnamortizedPrincipalBalanceOfInterestOnlyStrips" name="UnamortizedPrincipalBalanceOfInterestOnlyStrips" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="agnc_UnderPrimeBrokerAgreementsMember" name="UnderPrimeBrokerAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_UnrealizedGainOnDerivatives" name="UnrealizedGainOnDerivatives" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="agnc_UnrealizedLossOnDerivatives" name="UnrealizedLossOnDerivatives" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="agnc_WeightedAverageContractualInterestRateOfInterestOnlyStrips" name="WeightedAverageContractualInterestRateOfInterestOnlyStrips" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_WeightedAverageForwardStartDate" name="WeightedAverageForwardStartDate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_WeightedAverageLifeInterestOnlySecurities" name="WeightedAverageLifeInterestOnlySecurities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_WeightedAverageLifeOtherDebt" name="WeightedAverageLifeOtherDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="agnc_WeightedAverageYieldPercentage" name="WeightedAverageYieldPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
</xsd:schema>
